A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines

“Katalin Karikó’s story is an inspiration.”—Bill Gates

“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry

A KIRKUS REVIEWS BEST BOOK OF THE YEAR

Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.

Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.

Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.

Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.

An Instant New York Times Bestseller

“A knockout collection. … Sharp-edged satire deceptively wrapped like a box of Neuhaus chocolates, Table for Two is a winner.” —The New York Times

“Superb … This may be Towles’ best book yet. Each tale is as satisfying as a master chef’s main course, filled with drama, wit, erudition and, most of all, heart.” —Los Angeles Times

Millions of Amor Towles fans are in for a treat as he shares some of his shorter fiction: six stories based in New York City and a novella set in Golden Age Hollywood.

The New York stories, most of which take place around the year 2000, consider the fateful consequences that can spring from brief encounters and the delicate mechanics of compromise that operate at the heart of modern marriages.

In Towles’s novel Rules of Civility, the indomitable Evelyn Ross leaves New York City in September 1938 with the intention of returning home to Indiana. But as her train pulls into Chicago, where her parents are waiting, she instead extends her ticket to Los Angeles. Told from seven points of view, “Eve in Hollywood” describes how Eve crafts a new future for herself—and others—in a noirish tale that takes us through the movie sets, bungalows, and dive bars of Los Angeles.

Written with his signature wit, humor, and sophistication, Table for Two is another glittering addition to Towles’s canon of stylish and transporting fiction.