Category: Current Affairs (Page 4 of 7)

Current Affairs: Vote by Mail, Oct 15, 2020, 11:00

Host: Bob Baker

Discussion Leader: John Schlachtenhafen

https://www.wsj.com/articles/ballot-collection-battles-split-by-partisanship-move-through-courts-11590755212?st=4l91j4y2f2frvdw&reflink=article_email_share

Where Americans Can Vote by Mail in the 2020 Elections

Where Americans Can Vote by Mail in the 2020 Elections – The New York Times

Discussion at the Darien Library with Denise Merrill, CT Secretary of State

https://www.youtube.com/watch?v=mpTTSZeZI1s

Mail-Vote Madness in Pennsylvania

https://www.wsj.com/articles/mail-vote-madness-in-pennsylvania-11599865002?mod=hp_opin_po

Secretaries of states caution that election results could take weeks to determine:

https://fxn.ws/2Zd71TM

Testimony before the United States House of Representatives Judiciary Committee’s Subcommittee on the Constitution, Civil Rights, and Civil Liberties. “Protecting the Right to Vote During the COVID-19 Pandemic.”

HHRG-116-JU00-Wstate-FittonT-20200603

Millions of Americans are receiving absentee ballot applications from outside groups. Here’s what you need to know.
The large volume of mailed ballots expected for November’s election has raised concerns that the final result could be significantly delayed, with mailed or absentee ballots having to be verified and counted, in addition to in-person votes being tallied.
A federal judge in Texas ruled Tuesday that the state’s system of verifying signatures on mail-in ballots was unconstitutional and should be immediately corrected in advance of Election Day in November. | Fox News

Current Affairs: Income Inequality, Sept 17, 2020, 11:00

Your Host: Bob Baker

Discussion Leader: David Mace

Our current affairs group will talk about income inequality in America and what we should do about it.

 

Pew Survey – CA Sep 2020

The Black-White Wage Gap Is as Big as It Was in 1950

https://www.nytimes.com/2020/06/25/opinion/sunday/race-wage-gap.html?referringSource=articleShare

https://en.wikipedia.org/wiki/List_of_countries_by_income_equality

Racism’s Hidden Toll

https://www.nytimes.com/interactive/2020/08/11/opinion/us-coronavirus-black-mortality.html?referringSource=articleShare

How does income inequality affect our lives

Video recording of the discussion: https://youtu.be/8x4ej7hyeA4

 

 

Current Affairs: “Covid-19/ Status and Decisions to be Made”, Aug 27, 2020, 11:00

Host: Bob Baker

Discussion  Leader: Charles Salmans

Main topics are:

Covid infection and death rates
Latest data and possibility of “waves” this fall and next year, as in 1918

Tradeoff between economy and quarantines
Unemployment rates and issues of income replacement
Especially hard hit — hospitality and travel, small business
K-12 Schools, colleges and universities
Only the Federal government can print money; constraints on state and local budgets
Nations (and states) that have tightened after loosening (Australia, New Zealand, California, Florida)

Challenge of testing and contract tracing

Vaccine timetable
Vaccines under development
Challenge of final approvals
Manufacturing challenge to meet worldwide demand
Vaccine roll-out and priorities?
– Health care workers
– Elderly/Nursing Homes
– Other priority job categories (Police/fire, Food industry workers, Teachers)

Articles:
Covid treatment

The COvid Storm from WSJ

Covid Discussion Links Aug 2020 copy

Wall Street Journal: Lockdowns punish the economy. Months into the Covid-19 pandemic, evidence points to ways to slow the spread of the coronavirus at much lower economic cost.

https://www.wsj.com/articles/covid-lockdowns-economy-pandemic-recession-business-shutdown-sweden-coronavirus-11598281419?st=gq8fqbf9erwckxs&reflink=article_gmail_share

New York Times: “Why are US Cases Falling? Restrictions are Working.” Charts on nationwide cases, on four states where cases have declined from their peak (Florida, Arizona, Louisiana and South Carolina), and “Where the US falls among the 10 countries with the worst outbreaks.”
Effective reproduction rate: https://rt.live/

 

 

Current Affairs: Art Baron on Innovation, June 18, 2020, 11:00

Host: Charlie Goodyear

Discussion Leader: Art Baron

 

DISCUSSION OUTLINE ON INNOVATION 

Current Affairs, June 18, 2020 

AGENDA: 

  • The Science of Innovation 
  • The Digital Age . . . a Multi-Decade Transformation 
  • Winners and Losers . . . Lessons Learned . . . Market Considerations 
  • COVID . . . a Present Day Catalyst 
  • Potential Future Industry Disruptions 

===================================================================== 

  1. The Science of Innovation 

Innovation: The process of translating an idea or invention into a product, service, or business model that creates value for which customers will pay. 

Peter Drucker: “The Discipline of Innovation” HBR, August 2002 https://hbr.org/2002/08/the-discipline-of-innovation Areas of Opportunity: Unexpected Occurrences, Incongruities, Process Needs, Industry & Market Changes, Demographic Changes, Changes in Perception, New Knowledge 

Clayton Christensen: theory of “disruptive innovation”, first introduced in his 1997 book The Innovator’s Dilemma. Key insights: S-curve, market-creating innovations drive growth, (vs sustaining or efficiency innovations), innovations often come from outside the established incumbents. 

Henry Ford: “If I had asked people what they wanted, they would have said faster horses.” Steve Jobs: “You can’t just ask customers what they want and then try to give that to them. 

“Inspiring Innovation”, HBR August 2002 https://hbr.org/2002/08/inspiring-innovation 

Other Key Enablers: Simplicity, Focus, Diversity, Cross-discipline, Innovation Culture, Risk Acceptance . . . overcoming resistance to change 

 

  1. The Digital Age . . . a Multi-Decade Transformation 
  • Dramatic transformation fueled by, (among other things), Moore’s Law, Metcalfe’s Law 
  • “The Consumerization of IT” 

○ Increasingly, employees had more capabilities at home than at work 

○ Trickle down from consumer market to enterprise market, (much like prior generation trickle down from Military and NASA to private sector) 

  • Adoption rates of digital products accelerating virally. Many digital products have near zero marginal cost. 

○ Time to reach 50 million users 

■ Automobiles, 62 years 

■ Telephone, 50 years 

■ Credit Card, 28 years 

■ Mobile Phones, 12 years 

■ Facebook, 3 years 

■ PokemonGo, 19 days 

  • Brand new product categories, e.g. Streaming content, Smart phones, Virtual Assistants, AI, Social Media 
  • Increasingly Mobile First as the Innovation platform 
  • New Business Models are Transforming Industries 

○ SaaS, Cloud . . . new players, e.g. SalesForce.com, Workday 

○ Sharing Economy . . . Uber, Lyft, Airbnb 

  • Crisis driven change and leadership, e.g. Estonia, cyberattacks, 2007 

 

  1. Winners and Losers . . . Lessons Learned . . . Market Considerations 
  • Top valued companies as of 3/31/20: Microsoft, Apple, Amazon, Alphabet, Facebook. 

○ Leadership with brand new product & services categories 

  • Why did Microsoft miss the Internet in the mid-90’s, but recover and thrive, while Digital Equipment missed the microcomputer in the 80’s and didn’t 
  • Blackberry vs iPhone . . . dynamics in the marketplace 
  • Industry evolution:. Visacalc and the PC, then Lotus 123, and then Microsoft Excel 
  • Early internet successes, (AOL and Yahoo), superseded by newer ones, (Google and Facebook). 

○ As consumers became more proficient with the Internet, the access advantages of AOL and Yahoo gave way to the continuous innovation of companies like Google and Facebook. 

  • Xerox Parc, (GUI and Mouse), vs Apple 
  • A 19th Century Example: Steel industry leadership shift from U.K. to U.S. with Carnegie Steel’s adoption of Bessemer Steel Process. 
  • Fast Company: The World’s Most Innovative Companies, 2020 and 2019 

https://www.fastcompany.com/most-innovative-companies/2020 

https://www.fastcompany.com/most-innovative-companies/2019 

 

  1. COVID . . . a Present Day Catalyst 
  • Medical: Vaccines, Therapies, Ventilators, PPE,… 
  • Telehealth: technology available for years, but limited adoption due to business model, (insurance, provider fees) —> current urgency now driving coverage and deployment. Many post-COVID benefits. 
  • Online services 

○ Collaboration and Work from Home 

■ Zoom Video, simplicity vs competition, 20 million to 200m users, fierce competition: Microsoft Teams, Google Meet, Facebook, Apple,… 

■ Consumer apps, e.g. Caribu 

○ eCommerce Delivery, e.g. Amazon, Walmart 

○ Food delivery services, Restaurant services, Supermarket delivery, Instacart 

○ Location services enabling individual tracking, social distancing compliance, temperatures, etc. 

○ Behavior change, e.g. increase in digital banking across populations, Gucci, reducing runway fashion shows 

 

  1. Potential Future Industry Disruptions 
  • Healthcare 
  • Education, new cost dynamics, pathway for greater equality and opportunity 
  • CyberSecurity 
  • Food Supply, risks, (global hunger, climate change, drought, income security), reduce waste, (e.g. Apeel Sciences), new sources, (e.g. Beyond Meat, milk substitutes), new processes, (e.g. precision agriculture, restaurants delivery, kits, home cooking) 
  • Environment, Efficiency, Energy Transition, Pollution, Advanced Manufacturing, Circular Economy, Hydrogen, EVs 
  • Social/News Trust and Accountability, beginning to see some take action, (Twitter, Zoom), but others resist. Much more is needed given the harmful power of digital media. 
  • Resilience, Markets, Supply Chain, Transportation, Financial Systems, Global/Deglobalization Balance, . . . .

Current Affairs, Boeing, Thursday, April 16, 2020, at 11:00EDT

Tom Igoe will hold a virtual meeting discuss Boeing.   Charlie Goodyear

Discussion Questions:

  1. Has Boeing truly lost its way as a corporate leader in the US, and will it be able to recover? If so, what does the company need to do to change?
  2. Is there a global problem with pilot experience and training? Some people have suggested that the Indonesian and Ethiopian pilots involved in these crashes were part of organizations that were riven with systemic problems – inadequate pilot training and experience, poor aircraft maintenance and record keeping, and lax regulatory oversight
  3. Boeing has long had a reputation for designing its commercial airplanes premised on the notion that they are to be “flown” by experienced pilots who possess “airmanship qualities” and have the ability to think and act independently in the moment like true aviators. Does Boeing need to rethink aircraft design to totally automate the flight process? Does Airbus maintain a different philosophy in its approach to aircraft design and software?
  4. Does the current US system of aviation regulation make sense, or do we need to change the manner of regulation to eliminate conflicts and mitigate exposure to future regulatory lapses?
  5. How do these crashes affect the standing of the US in the world of global commercial aviation and do we need to improve coordination and cooperation among foreign regulatory bodies on aircraft development, real time aviation and safety advisories, and analyses of the causes of crashes?

Synopsis:  The Boeing 737 MAX Debacle – DMA Current Affairs Discussion Paper

Readings:

  • Boeing’s principles and vision, as articulated on its website
  • New York Times Magazine lengthy and provocative article entitled “What Really Caused the Deadly Crashes,” by William Langewiesche
  • Detailed and well documented reports from Wikipedia covering (i) the 737 MAX groundings; (ii) the Lion Air crash; (iii) the Ethiopian Airlines crash; (iv) the design and purpose of the critical MCAS software and analysis of its flaws; and (v) the 737 MAX certification process
  • An article on the emerging friction between US and European aviation regulators
  • The recent preliminary report of the US House Committee on Transportation & Infrastructure
  • The preliminary accident investigation reports from the Indonesian NTSC and the Ethiopian ECAA on the two crashes
  • Boeing’s recent Securities Exchange Act public filings covering (i) the company’s major risk factors, (ii) Boeing’s exposure to claims and customer payment demands and (iii) the company’s liquidity challenges and new credit facilities
  • Sample articles in the financial press on the ultimate probable cost to Boeing and an assessment of whether the company has “lost its way”
  • My correspondence with David Mace, a fellow DMA book group member, on the subject of causation, comparing the Chernobyl accident (as recounted in detail in the book, Midnight in Chernobyl) with the Boeing 737 crashes

http://www.boeing.com/principles/vision.page

https://www.nytimes.com/2019/09/18/magazine/boeing-737-max-crashes.html

https://en.wikipedia.org/wiki/Boeing_737_MAX_groundings

https://en.wikipedia.org/wiki/Lion_Air_Flight_610

https://en.wikipedia.org/wiki/Ethiopian_Airlines_Flight_302

https://en.wikipedia.org/wiki/Maneuvering_Characteristics_Augmentation_System

https://en.wikipedia.org/wiki/Boeing_737_MAX_certification#Boeing_737_safety_analysis

https://transportation.house.gov/news/press-releases/nearly-one-year-after-launching-its-boeing-737-max-investigation-house-transportation-committee-issues-preliminary-investigative-findings-

https://transportation.house.gov/imo/media/doc/TI%20Preliminary%20Investigative%20Findings%20Boeing%20737%20MAX%20March%202020.pdf

http://knkt.dephub.go.id/knkt/ntsc_aviation/baru/pre/2018/2018%20-%20035%20-%20PK-LQP%20Preliminary%20Report.pdf

https://web.archive.org/web/20190404161640/http://www.ecaa.gov.et/documents/20435/0/Preliminary+Report+B737-800MAX+%2C%28ET-AVJ%29.pdf/4c65422d-5e4f-4689-9c58-d7af1ee17f3e

Chernobyl Accident Versus 737 Crashes — Causation Issues

Boeing Report – Yahoo! Finance Jan 2020

Boeing’s 737 Max Bill to be over $25 Billion (Jan 22)

Boeing Form 8-K Excerpts — New Credit Lines

Boeing 10-K Excerpts – Risk Factors and Liquidity

Current Affairs, Talkin’ Trash, February 20, 2020

8:30am, Lilian Gade Room at the DCA.

Cliff van Voorhees and Carolyn Bayne will discuss the challenges of recycling in Darien.

Introductory slide show.

DMA Recycling

Examples of what should and should not be in single stream recycling:

Click below to see what’s allowed and not allowed in Darien Single Stream.  Just because it isn’t listed here, doesn’t mean it can’t be recycled – there are separate areas for paint, lightbulbs, batteries, electronics, tires, appliances, food waste, metal, large plastic, yard waste, mattresses, clothes, corrugated, plastic bags, construction debris, …  And the Swap Shop is a way to recycle usable stuff.  (Or gain more clutter you don’t really want.)   You can also pick up shredded mulch, leaf compost, and sometimes food compost.

2019_Darien_Single_Stream_Recycling_(Full_List)

 

A tour of City Carting Recycling Center. (hover over picture to stop scrolling)

Commercial Haulers

The haulers separate trash from SSR, even though many people seem to think they do not. I believe they do for two main reasons:

  1. it’s the law and their licenses could be revoked if they are found in violation;
  2. Darien charges haulers to tip MSW but not SSR.  Free tipping of SSR is an incentive to separate – and recycle – SSR. We are one of the few remaining municipalities that continues to get paid for SSR, but that could change when our contract is renegotiated.

It’s also worth noting that the haulers are only required to recycle what goes in the blue bin (ie our SSR list); many of the other items we recycle (ie batteries, light bulbs, e-waste, paint, etc.) must be brought to our facility.  We ALWAYS recommend that residents who employ a hauler also get a dump sticker so that they can recycle these additional materials; their permits are priced much lower to account for the fact that they are primarily bringing recyclables and not regular household trash.  Note that Seniors can get a free permit.

 

CT’s problem with waste from “Hartford Current:”
https://www.courant.com/news/connecticut/hc-news-ct-outofstate-trash-disposal-20191228-hprk52k2hjbzlj7xz2lztug74q-story.html

 

Economics and Science of Recycling from “Popular Mechanics” (note date is 2008 before China’s ban on imports):

https://www.popularmechanics.com/science/environment/a3752/4291566/

 

Problems with Recycling in Asia from the “Financial Times:”
https://www.ft.com/content/360e2524-d71a-11e8-a854-33d6f82e62f8

 

Micro-plastics and their effects on humans from “The Conversation:”
https://theconversation.com/we-are-guinea-pigs-in-a-worldwide-experiment-on-microplastics-97514

 

Recycling facts from Recycle Across America:
https://www.recycleacrossamerica.org/recycling-facts

https://www.bloomberg.com/graphics/2020-world-plastic-waste/?fbclid=IwAR0OkLn4IffTQ-O4dN9ItuQ73fBgdCSoyxg_Fi6v1ZG6Vfy751y3cR-g32g

CT’s Policies from the CT Mirror.
https://ctmirror.org/2020/02/17/is-connecticuts-outdated-recycling-system-in-line-for-an-overhaul/?utm_source=Connecticut+Mirror+Mailing+List&utm_campaign=b6d6010e90-DAILY_BRIEFING_MORNING&utm_medium=email&utm_term=0_571d22f8e4-b6d6010e90-68155097

Current Affairs- Business Roundtable: Purpose of a Corporation, March 19, 2020, 11:00 EDT

DMA Current Affairs.  The Purpose of the Corporation hosted by Bob Baker
We have licensed audio/video conferencing software and are going to (try to) hold the Current Affairs meeting over the internet.
As always, you should review the material in advance on the website:
You should keep the post open to follow Bob’s opening remarks.
The meeting will start at 11:00 EDT.
We’ve had some issues with connectivity.  It could that the company’s capacity is overwhelmed – many, many people are going on-line or it could be idiosyncrasies with a person’s PC.  (There is no chance it is the skill of the user.)
For simple dial in use the following numbers from any phone.
United States: +1 (872) 240-3412
Access Code: 132-263-437
For the intrepid you can try joining on-line.  The meeting will open about 10:30.  We won’t have time to troubleshoot so if there are technical problems, use the dial in number.

Please join my meeting from your computer, tablet or smartphone.
https://www.gotomeet.me/DMAdarien/currentaffairs

New to GoToMeeting? Get the app now and be ready when your first meeting starts: https://global.gotomeeting.com/install/132263437

Business Roundtable—Purpose of a Corporation

Pre- August 2019 Maximize Shareholder Value

Corporate Responsibility per Milton Friedman

1970 essay- Maximize Returns to Shareholder

Friedman’s thesis: Corporations are not to make contributions for

“social causes”, shareholders can choose what to give.

Further- Corporations are to obey all laws and regulations.

If corporations make “contributions”, the directors must

conclude such donations create good will and enhance sales.

Current example: Orvis gives 5% of pretax profits for “environmental

causes”. (Could they give 15%?

 

Comments from Harvard Law School Forum
Re: Business Roundtable Statement on Corporate Mission

Corporate Directors have a fiduciary duty to act in shareholder interest
Thus, decisions not in shareholder interest are illegal

Actions taken by directors will be presumed to be in shareholder interest or they would not be taken.
Directors must adhere to the law so that new Legislative mandates may promote or presume to benefit other stakeholders, but at a cost to shareholders.

Overall question:  To what extent do we desire the government to impose
rules that will decrease business profits in order to strive for other benefits

 

What does the Business Roundtable expect or hope to change with revised statement of purpose?

Former “purpose”: “Maximize shareholder Value”

New “purpose”: “Act to benefit all stakeholders”

Stakeholders: customers, employees, suppliers, communities, and shareholders

Possible intentions:

Change corporate reporting on selective topics?

Motivate investments into areas not directly in shareholder interest?

Motivate shareholder resolutions on new corporate action

Bring about new government rules on business actions

Potential areas of Government mandates:  ESG

(Environment, Social, Government)

Action regarding global warming;

Other environment improvement measures

Reduction of income inequality

Increase diversity in management personnel

Impose unnecessary costs for named investments

Establish more “days off” for employees

 

 

 

 

From the WSJ. Financial Advisers Turn to ESG, Warily – WSJ

IEA warns oil companies doing nothing on emissions is not an option
https://eresearch.fidelity.com/eresearch/goto/evaluate/news/basicNewsStory.jhtml?symbols=XOM&storyid=202001191929RTRSNEWSCOMBINED_KBN1ZJ005-OUSBS_1

Larry Fink’s Latest Sermon

Capitalism, Alone’ Review: Inclined Toward Inequality
Capitalism Alone

Business Roundtable Redefines the Purpose of a Corporation to Promote ‘An Economy That Serves All Americans’

https://lucidmanager.org/milton-friedman-corporate-social-responsibility/

https://corpgov.law.harvard.edu/2019/09/26/analysis-of-the-business-roundtable-statement/

https://www.coursehero.com/file/8478280/Purpose-of-the-Corporation/

The Davos Crowd Embraces Big Global Government – WSJ

The ‘Stakeholders’ vs. the People – WSJ

Bloomberg’s Business Nanny – WSJ

5G Wireless Networks. December 9, 2019

New date and place:  DCA second floor for 8:15- 9:15 on Monday December 9.

Discussion  leader: Jim Phillips

https://www.wsj.com/articles/the-downside-of-5g-overwhelmed-cities-torn-up-streets-a-decade-until-completion-11561780801

https://www.alvareztg.com/the-pros-and-cons-of-5g/

https://www.celltowerleaseexperts.com/cell-tower-lease-news/pros-cons-how-will-5g-impact-your-city/

https://www.bbc.com/news/world-europe-48616174

https://www.investors.com/news/technology/5g-stocks-5g-wireless-stocks/

https://www.nytimes.com/2019/07/16/science/5g-cellphones-wireless-cancer.html

https://www.barrons.com/articles/5g-stock-opportunities-51572025082?mod=hp_DAY_7

https://www.wsj.com/articles/u-s-government-is-tripping-over-itself-in-race-to-dominate-5g-technology-11573527840?mod=hp_lead_pos10

https://ieeexplore.ieee.org/abstract/document/6894452

 

 

Current Affairs: The Microbiome, Nov 21, 2019

Discussion leaders: Jack Fitzgibbons & Gary Banks

The microbiome is the genetic material of all the microbes (bacteria, fungi, protozoa and viruses) that live on and inside the human body.

It is one of the most promising, yet challenging topics in modern medicine.

The Microbiome is a new field with implications for many different areas including obesity research, causes of arthritis, intestinal ailments and psychiatric illnesses.

 

Here’s a short introduction to get you started.

https://depts.washington.edu/ceeh/downloads/FF_Microbiome.pdf

Introduction from MSK:

https://www.mskcc.org/blog/what-your-microbiome-and-three-things-could-change-it

Good overview of the microbiome and the many diseases influenced by it.

https://learn.genetics.utah.edu/content/microbiome/disease/

Amish vs Hutterites – asthma

https://www.nytimes.com/2016/08/04/opinion/health-secrets-of-the-amish.html

The Gut Microbiome and Its Role in Obesity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082693/

 

New Study Reveals Gut Microbes May Help Protect People Having a Bone Marrow Transplant

https://www.mskcc.org/press-releases/new-study-reveals-gut-microbes-may-help-protect-people-having-bone-marrow-transplant

From Harvard:

https://www.hsph.harvard.edu/magazine/magazine_article/bugs-in-the-system/?utm_source=Facebook&utm_medium=Social&utm_campaign=Chan-Facebook-General

 

From the Harvard Medical School

https://www.hsph.harvard.edu/nutritionsource/microbiome

Antibiotics can disrupt the gut ecosystem for months.

https://www.nytimes.com/2018/12/21/well/live/does-the-gut-microbiome-ever-fully-recover-from-antibiotics.html?searchResultPosition=9

Cancer Immunotherapy and the Microbiome.  A 6 minute video from Johns Hopkins

https://www.hopkinsmedicine.org/profiles/results/directory/profile/0002419/cynthia-sears

Prostate Cancer Therapy and the Gut Microbiome

https://www.hopkinsmedicine.org/brady-urology-institute/patient-information/books-publications/articles/prostate-cancer-therapy-and-the-gut-microbiome

Are ready for a challenge?  This is from journal Nature.  Not easy for the layman.  The first couple of pages give a good idea how complex and active a research area this is.

https://www.nature.com/articles/s41586-019-1238-8

https://www.nature.com/articles/s41392-019-0074-5

 

Animals

The microbiome is important in animals.  For instance, here is an article where altering the microbiome of a cow reduced methane production by 95%.

https://animalmicrobiome.biomedcentral.com/articles/10.1186/s42523-019-0004-4

Just to give you an idea how active the research is in animals.  Here are 4 journals that are starting up.

 

Antimicrobial resistance and the microbiome

MicrobiomeEnvironmental Microbiome and Animal Microbiome are coming together to launch a special series inviting authors to submit their research pertaining to antimicrobial resistance (AMR) and the microbiome.

New Content Item

The emergence and spread of AMR can only be described as a catastrophic problem for human and animal health. It is projected that there would be more deaths due to AMR than cancer by 2050.

During the last decade a large number of studies have reported the emergence and spread of antimicrobial resistance genes (ARG) and defined in detail how these are mobilised between pathogens and also within communities of bacteria. The impact of antibiotics on microbiomes particularly those of humans and animals is a cause for concern and can alter physiology quite dramatically. In addition the spread of ARG to these microbiomes has been reported and occurs on a global scale clearly indicated in studies of sewage and waste water treatment plants. Further spread may occur under selective conditions in the presence of antibiotics in sewage and other biocides such as detergents both of which could cause significant changes in diversity. We need to understand the impacts of ingression of ARG into microbiomes and consider the wider issue of AMR spread into the environment.

The importance of human microbiomes is indisputable now as many new aspects of their roles have emerged in the past few years and continue to build a complex picture of metabolic interactions with their hosts. Similarly, animal and plant microbiomes studies have provided an exciting view into the potential benefits of healthy, diverse and stable microbiomes for sustainable agriculture. Understanding the persistence and spread of ARG in agricultural and other food production systems such as aquaculture will be critical for food safety and production. We are just beginning to reveal the importance of microbial assemblages in the environment for both bioremediation and biodegradation in addition to the vital roles played in nutrient cycles. Antimicrobial agents can have impact on all these activities in addition to spreading new gene combinations due to the rapid mobilisation of ARGs due to the highly selective effects of antibiotic therapy. Whilst some antibiotics are natural products others are xenobiotics and remain and persist in the environment and mobile ARG will spread as a result of selection. Most naturally occurring resistance genes are chromosomal and further work is needed to investigate these impacts.

Microbiomes may work syntrophically to degrade recalcitrant compounds and recent research has demonstrated the emergence of antibiotic biodegraders within the environment and these bacteria may provide the answer to reduce the persistence of antibiotics and their detrimental effects in nature. By understanding the natural role of antibiotics produced in nature we may find the clues to avoiding the arms race of ever increasing resistance in the face of novel drugs, streptomycin production gene clusters are still found in soil streptomycetes and were dated thought to have emerged several million years ago yet they are still apparently useful in nature today. Further research will inform new ways to administer antibiotics, new types of drugs and new ways to combat resistance.

This is a research are for our an upcoming speaker, Dr. Sarah Kahn

The microbiota–gut–brain axis

Microbiota-gut-brain jigsawOur understanding of the complex and bidirectional signalling relationship between the gastrointestinal tract and the brain is evolving quickly. This relationship, dubbed the microbiota-gut-brain axis, is thought to be involved in many aspects of homeostasis in addition to the pathogenesis of several diseases, ranging from neurological and degenerative conditions to autoimmune diseases.

This cross-journal collection brings together both human and animal studies covering all aspects of the microbiota-gut-brain axis’ role in health and disease, as well as its therapeutic potential. The participating journals, spanning both neuroscience and microbiology, are listed below.

Submissions should be formatted according to individual journal guidelines. Please indicate clearly in the cover letter that the manuscript is to be considered for this collection.

All manuscripts will undergo standard peer review, and must be submitted through the relevant journal’s online submission system by 31st December 2019.

 

Engineering optimal livestock microbiomes

Cows eating hay © Image by skeeze from Pixabay

The human population is predicted to reach approximately 9.7 billion by 2050. Consequently, ensuring future food availability, safety and nutritional content is crucial. Gastrointestinal tract microbiomes of livestock animals play a crucial role in processing dietary components and providing the host with the necessary nutrients for growth. Recently, the terminology of the holobiont (the host and its microbiota) has been introduced in recognition of the importance of the interactions between the host and its microbiota and their influence on host phenotype, and the need to consider them as one unit.

Whilst livestock holobionts have evolved over millennia, this is often does not result in increased food availability through enhanced production, as the GI tract microbes prioritise their own nutrition before the nutrition of the host.  This means that feed conversion is often sub-optimal and therefore understanding what is the ‘best’ microbiome from a production perspective, and biotic and abiotic factors which govern microbiome composition, are key to our ability to feed the human population in the future.

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