A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines
“Katalin Karikó’s story is an inspiration.”—Bill Gates
“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry
A KIRKUS REVIEWS BEST BOOK OF THE YEAR
Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.
Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.
Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.
Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.
In announcing Erin’s appointment last August as executive director of the DCA, the board described Erin as a seasoned executive with over 25 years of experience in the development of business and brand strategies, digital and communication plans, and integrated campaigns for some of the world’s most recognized and most well-loved brands. Those brands included Nike, ESPN, American Express and Pepsi. She has brought her vision and experience to bear on revitalizing the DCA for a new era.
Jim Himes represents Connecticut’s 4th District in the United States House of Representatives where he is serving his eighth term. He serves as Ranking Member of the House Permanent Select Committee on Intelligence, and on the House Financial Services Committee.
Local author Tim Manners will give a special talk about his book, Schoolboy: The Untold Journey of a Yankees Hero (University of Nebraska Press). Manners, who was a recent guest speaker at the Baseball Hall of Fame in Cooperstown, N.Y., co-authored the book with Waite “Schoolboy” Hoyt, using a trove of records and writings from Hoyt, who passed away in 1984. Hoyt’s improbable baseball journey began when the 1915 New York Giants signed him as a high school junior, for no pay and a five-dollar bonus. After nearly having both his hands amputated and cavorting with men twice his age in the hardscrabble Minor Leagues, he somehow ended up as the best pitcher for the New York Yankees and teammate with such legends as Babe Ruth and Lou Gehrig. You don’t have to be a fan of baseball to be fascinated by Hoyt’s astonishing life story!
Tim Manners is a writer, communications consultant and baseball fan. A magna cum laude graduate of Tufts University with a BA in history, he is a former FM-radio disc jockey, publicist and magazine publisher. Currently an essay specialist with The Manners Group, he is co-author of “Schoolboy: The Untold Journey of a Yankees Hero” (2024) with baseball great Waite Hoyt (University of Nebraska Press) and “Relevance: Making Stuff That Matters” (2008), published by Penguin/Portfolio.